Add # 304 Mucosal Barrier Function Panel for $160 plus lab fees
The Mucosal Barrier Function test uses a single saliva sample to assess the level of secretory immunoglobulin A (sIgA) and the levels of free IgA and IgM to a group of common dietary proteins (corn, cow’s milk, egg, gliadin, and soy); enteric yeast (Candida albicans); a group of enteric aerobic bacteria (Escherichia coli and E. enterococcus); and a group of enteric anaerobic bacteria (Bacteroides fragilis and Clostridium perfringens). The proteins and organisms are tested as separate groups; the highest reading in each group is reported.
The lining of the gastrointestinal tract, from the mouth to the anus, is covered by a mucosal barrier, which provides our first line immune defense against pathogens and a mechanism for proper processing of food antigens. The mucosal barrier contains specific immune defenses including mucosal antibodies; IgA, IgG and IgM. A healthy mucosal barrier defense contains sufficient antibodies and responds to normally encountered antigens and deals with them appropriately. All of the dietary proteins, yeasts, and bacteria used in this test are normally found in the human body or diet. IgA is the predominant antibody quantitatively in the mucosal immune system.
Secretory IgA Level
This is an important indicator of the strength of mucosal immunity and can help to establish the validity of other Ig values.
If total sIgA is elevated an infection exists and further testing is recommended to determine its type.
If total sIgA is low it can indicate compromised mucosal immunity, however, it is a measurement at a point in time; it needs to be looked at over time and correlated with cortisol rhythm and lifestyle.
Assessing the levels of antibodies to foods is important in determining the cause of possible chronic gastrointestinal inflammation. Such inflammation can be accompanied by symptoms, or it can be sub clinical. If immune markers to dietary proteins are elevated, it is important to do further testing to determine which food the mucosal immune system is reacting to.
If IgA is elevated in the yeast compartment it means that Candida is attempting to invade the intestinal mucosa.
Determining the levels and ratio of bacterial groups to each other helps assess digestive and absorptive function. The ratios of the levels of the same specific immune marker for aerobic and anaerobic bacteria (i.e. IgA aerobic/IgA anaerobic) should be about one to one. If these ratios are >2 or <0.5, then a dysbiotic condition exists. Specific infections should be ruled in or ruled out. However, dysbiosis can result from a course of antibiotic therapy with out proper efforts to recolonize the gut.
If either of the antibodies (IgA or IgM) in each compartment (dietary proteins, yeast, aerobic bacteria and anaerobic bacteria) is elevated then the gut is leaky and proteins (antigens) are entering the general circulation.
Test Kit #304 - Mucosal Barrier Function Panel Results Include:
Conditions that may be assessed include an abnormal ratio of aerobic-to-anaerobic bacteria, pathogen or yeast overgrowth, intestinal mucosal immune dysfunction, systemic immune deficiency, autoimmunity, food allergy, gluten enteropathy, malabsorption, and “leaky gut.”
Test Results Include:
For more Information contact Karl K Scott at firstname.lastname@example.org
- Secretory IgA
- Plus IgM and IgA antibodies to dietary proteins, yeasts, aerobic & anaerobic bacteria
- Sample required: 4 ml saliva
- Lab reporting time: 14 - 18 business days
- Lab Fee $245